SEATTLE — It wasn’t Ben Gamel’s inability to make a tough diving catch Tuesday night in the 11th inning on Albert Pujols’ slicing drive to right field that ultimately sent the Mariners to a 6-4 loss to the Los Angeles Angels.

It was what came next.

Gamel overthrew the relay man, second baseman Robinson Cano, as Mike Trout raced around the bases with the tie-breaking run. That eliminated any chance for a play at the plate.

James Pazos (0-1) started the 11th inning by striking out Kole Calhoun, who had given the Angels a 4-3 lead in the eighth inning with a two-run homer against Edwin Diaz.

Trout then drew a four-pitch walk, but Pazos jumped ahead 0-2 on Pujols before allowing the count to go full.

“Just too fine in trying to put him away,” Pazos said. “I was trying to make a pitch too nasty, and I ended up losing him.”

Pujols sliced a 97-mph fastball to right. Gamel raced over and made a diving attempt that came up short. Trout held up to see whether Gamel would make the catch but began sprinting when the ball hit the ground.

“A hard-hit line drive toward the line,” Gamel said. “I just came up a little short. It was the only play I thought I had at the time. If I stop and try to keep it in front, I think it’s going to skip off the grass.

“I think it was the only play I had.”

The high throw to Cano, though, was decisive.

“I thought we had a chance because Trout was not running on the play,” Servais said. “We didn’t execute late in the game, pitching or defense. We let Pujols get too big of a lead and take third on us there.”

Reliever Deolis Guerra (2-1) got the victory by pitching two scoreless innings.

The Mariners built leads of 2-0 and 3-2 against LA starter Matt Shoemaker, who was making his first appearance at Safeco Field since getting hit in the head last Sept. 4 by a Kyle Seager line drive.

Tony Zych escaped a two-on threat in the seventh inning but began the eighth by hitting Cameron Maybin with a full-count slider.

Zych retired the next two hitters before the the Mariners summoned Diaz to face the heart of the Angels’ lineup, starting with Calhoun.

Maybin stole second base on Diaz’s second pitch before Calhoun golfed a 3-1 fastball — a 98-mph fastball — into the right-field seats.

“Eddie’s been our guy,” Servais said. “He’s been one of our best guys. Right, left. It doesn’t really matter. He made a mistake. He got a pitch in a spot that Calhoun could handle, and he didn’t miss it.”

Diaz had allowed just one run in 6 1/3 innings over six appearances since the Angels rocked him for three runs in two-thirds of an inning on April 9 in erasing a six-run deficit in the ninth inning.

The Mariners pulled even in the ninth inning against Angels closer Bud Norris after Jarrod Dyson pushed a one-out single through the left side.

A two-out walk to Gamel put runners on first and second for Robinson Cano, who grounded an RBI single to left.

The Mariners took a 3-2 lead when Danny Valencia turned on a 2-2 slider from Shoemaker with one out in the sixth inning. Valencia sent a 364-foot drive to left for his second homer on the year.