While culinary mushrooms are renowned for their flavor, texture, and rich content of essential nutrients, consuming mushrooms has long been a staple of traditional medicine in various countries worldwide. This is because they can produce an extensive range of beneficial health effects.
Perhaps none are more impressive than their function as biological response modifiers. This means they can boost the immune system and allow edible mushrooms to do everything from treating issues like inflammatory bowel disease to promoting cytokine production and immune system health and functions.
The only problem is that with so many edible mushroom extracts, it can be hard to know which to use. That is why we have made our guide to the best medicinal mushroom supplements to boost the immune system and give everyone all the information they need to help them stay fully fit and healthy.
The 6 Best Supplements With Medicinal Mushrooms To Support Immune Function
Nootrum Mushrooms
Nootrum Mushrooms is a supplement designed using potent doses of 10 different medicinal mushrooms rich in beta-glucans, which is excellent for boosting immune function. It can also improve your brain health and functions, providing additional mental and physical health benefits.
Nootrum Mushrooms consist of reishi mushroom extract, shiitake mushroom extract, lion’s mane mushroom extract, cordyceps sinensis powder, and a blend of maitake mushroom, turkey tail mushroom, chaga mushroom, royal sun agaricus mushroom, white button mushroom, and black fungus extracts.
Lion’s mane mushrooms promote a functional and healthy immune system and brain, improve blood flow to the brain, nerve growth factor, and the growth and repair of neurites and brain and nerve cells, and reduce inflammation and your blood pressure, blood sugar, blood lipid, and cholesterol levels.
Cordyceps extract comes from a rare caterpillar fungus. It supports a functioning and healthy immune system, brain, heart, and testicles, boosts brain cell growth, mental clarity, and physical performance, and treats aging, inflammation, cognitive decline, arthritis, diabetes, diarrhea, headaches, and tumors.
Reishi mushrooms support a robust immune system and a healthy brain and urinary tract; boost your mood, sleep quality, strength, and stamina; relieve stress, anxiety, and blood sugar and blood pressure levels; and prevent or treat metabolic syndrome, fatigue, and other health conditions.
Shiitake mushrooms are high in vitamins B and D, offering numerous mental and physical health benefits. They can improve immune function, boost your heart and brain health, energy levels, and weight loss, and help reduce inflammation and combat various chronic health issues.
The maitake mushroom (grifola frondosa) contains antioxidants, beta-glucans, minerals, and vitamins. It can boost immune function, improve brain health, reduce blood sugar, blood pressure, and cholesterol levels, and help combat various diseases, illnesses, and health issues.
The turkey tail mushroom is a polypore mushroom found worldwide. Rich in antioxidants, beta-glucans, and polysaccharides K, it can enhance immune function, gut health, digestion, physical performance, and mental abilities, reduce inflammation and blood sugar levels, and help combat type 2 diabetes.
Chaga mushrooms are edible macroscopic fungi found on birch trees full of melanin, polyphenols, triterpenoids, and polysaccharides. They provide immune modulation, boost gut health, reduce blood sugar and cholesterol levels, and prevent or combat cell mutation, fatigue, and some chronic illnesses.
Royal sun agaricus mushrooms can boost the innate immune system and liver health and functions and reduce or prevent stress, hunger cravings, mood swings, allergic reactions, physical weakness, blood sugar and cholesterol levels, alopecia, arthritis, and heart, digestive, and other chronic health issues.
White button mushrooms can boost immune responses by increasing vital immune compound production like white blood cells, T cells, B cells, and other natural killer immune cells. This will reduce or prevent oxidative stress and damage, inflammation, and other chronic health conditions.
They can protect the prostate, boost gut health and functions, and lean muscle growth.
Black fungus extract is made from medicinal mushrooms rich in probiotics, antioxidants, beta-glucans, and fiber. It boosts gut, liver, brain, and immune health and functions, reduces cholesterol, protects the cells from free radicals and oxidative damage, and aids blood flow to the brain and circulation.
By combining potent doses of so many clinically proven 10:1 extracts of immune-boosting mushrooms, Nootrum Mushrooms can safely and effectively provide immune support, reduce oxidative stress and damage, and enhance your mental and physical health and functions from almost every angle.
When you then add that it is also very reasonably priced and directly aids the production of natural killer cells, Nootrum Mushrooms is easily the best choice for people who are interested in consuming mushrooms for the immune-boosting properties that they possess.
Pros
- Uses a wide range of medicinal mushrooms that promote adaptive immune responses and boost your mental and physical health
- All active compounds used are high-quality, potent medicinal mushroom 10:1 extracts.
- It has no artificial flavors and uses only organic medicinal mushrooms
- Reasonably priced
Cons
- As a relatively new supplement, reviews from past users are still quite limited.
- Must be purchased directly from the official Nootrum website
NutriFlair Premium Mushroom Complex
Nutriflair Premium Mushroom Complex are vegan-friendly, reasonably priced, GMO-free medicinal mushroom capsules designed to boost people’s immune systems, memory, focus, mental clarity, and vitality and keep their bodies healthy by combining the extracts of ten different medicinal mushrooms.
Its formula consists of lion’s mane mushrooms, cordyceps mushrooms, reishi mushrooms, chaga mushrooms, maitake mushrooms (grifola frondosa), turkey tail mushrooms, shiitake mushrooms, enoki mushrooms, Agaricus mushrooms, and oyster mushrooms.
Agaricus, cordyceps, chaga, lion’s mane, maitake, reishi, shiitake, and turkey tail mushrooms have all been in the other products we have examined in various dosages, and they still have all of the same mental, physical, and immune-boosting properties that they did before, so offer similar health benefits.
Enoki mushrooms contain polysaccharides, protein, antibacterial, antiviral, anti-inflammatory compounds, and other nutrients. They may boost brain, gut, heart, and immune system health and functions and weight loss, reduce inflammation, and treat chronic allergies, diseases, and viruses.
Oyster mushrooms are unique, as they are carnivorous fungi that eat insects and worms, absorb many of the bioactive compounds they contain, and take on their antioxidant properties.
This enables them to improve your immune response, bone mineral density, and vitamin D levels, prevent or treat anemia, arthritis, osteoporosis, and other health issues, lower your blood pressure and cholesterol levels, and boost your brain health, functions, and overall well-being.
There are a few issues with Nutriflair Premium Mushroom Complex we must mention, though.
Many of the proven medicinal mushrooms are present in doses that are far too low to produce immune cells or deliver other health benefits to their optimal level. The enoki mushrooms and oyster mushrooms also need more research to prove they provide immune support conclusively.
There have even been a few reports of people experiencing gastrointestinal side effects when using the supplement.
However, Nutriflair Premium Mushroom Complex can benefit the immune system and is one of the only supplements to use reishi, enoki, and lion’s mane extracts together, all of which are reasonably dosed, making it one of the best immune boosting supplements for people seeking this specific combination.
Pros
- One of the only supplements to feature a potent dose of reishi, enoki, and lion’s mane mushrooms
- One of the cheaper ways to get mushroom immune support
- Vegan-friendly and non-GMO
Cons
- Most medicinal mushrooms are used in doses too low to boost the immune system notably.
- Some bioactive compounds need more research to prove they benefit the immune system.
- There have been some reports of users experiencing side effects
Om Mushrooms Master Blend
Om Mushrooms Master Blend is an organic, kosher, vegan, gluten-free, and keto and paleo-friendly supplement that is designed to offer a range of beneficial effects, including boosting vitality, energy levels, mental clarity, and your immune system, keeping the gut and brain healthy, and reducing stress.
Om Mushrooms Master Blend is made with a proprietary blend of 10 organic medicinal mushrooms. It includes lion’s mane, cordyceps, king trumpet (oyster), turkey tail, maitake, reishi, shiitake, antrodia, himematsutake (agaricus), and chaga mushrooms, as well as ashwagandha root extract.
Lion’s mane, cordyceps, oyster, turkey tail, maitake, reishi, Agaricus, chaga, and shiitake mushrooms have all been seen in the other supplements we have looked at and will again provide the same health benefits to some degree.
Antrodia mushrooms are a fungus that promotes a healthy immune response, protects the liver, decreases inflammation and high blood pressure levels, combat abdominal pain, diarrhea, and certain chronic medical conditions, and even help cure hangover symptoms.
Ashwagandha extract is an adaptogen made from the roots of the evergreen winter cherry plant. It has long been trendy in traditional Chinese medicine for the immune compounds it contains and the vast range of beneficial effects it can produce.
It boosts brain, heart, immune system, and sex organ health and functions, fertility, sleep quality, weight loss, physical performance, energy levels, mental clarity, memory, focus, muscle size and strength, and the production of testosterone and NK cells, and reduces stress, anxiety, and blood sugar levels.
Admittedly, there are a couple of issues with Om Mushrooms Master Blend that do need addressing.
Most medicinal mushrooms and ashwagandha have been proven beneficial for the immune system. Still, many are present in doses lower than required to produce optimal effects. Antrodia and oyster mushrooms need more research to prove that they benefit the immune system.
However, as it can boost the immune system, is reasonably priced, and contains one of the more potent doses of turkey tail mushrooms that you will find in any supplements, it is a good choice for people who are shopping on a budget or looking to make the most of the benefits that specific mushroom can offer.
Being available in gummy and powder form and traditional capsules makes it a good choice for people who want to use mushroom extracts but who have issues or do not like swallowing pills or capsules.
Pros
- Reasonably priced
- It contains a range of medicinal mushrooms and ingredients proven to boost the immune system, including one of the most potent doses of turkey tail mushrooms you are likely to find
- Available as capsules, gummies, and a powder
Cons
- Many medicinal mushrooms are present in doses that are too low to produce optimal effects.
- Not all medicinal mushrooms have been conclusively proven to boost the immune system.
Stonehenge Health Dynamic Mushrooms
Stonehenge Health Dynamic Mushrooms is a premium supplement that supports the antioxidant and immune system and improves memory and focus. It is GMO-free, vegetarian-friendly, and made in GMP-certified facilities.
The Stonehenge Health Dynamic Mushrooms formula contains a potent dose of lion’s mane 10:1 extract, which is then supported by chaga mushroom 10:1 extract, maitake mushroom 4:1 extract, shiitake mushroom 4:1 extract, and reishi extract with 30% polysaccharides.
All of the medicinal mushrooms in the Stonehenge Health Dynamic Mushrooms formula have been seen in the previous supplements that we have examined. They will provide all the same immune system and overall health effects as before to some degree, although they will vary a little based on the dosages.
They will enhance the immune system, the production of immune cells like B cells, T cells, and NK cells, nerve, heart and brain health, function and repair, sleep quality, fat loss, energy and testosterone levels, concentration, focus, blood flow, the growth of beneficial bacteria, nerve growth factor, and your mood.
They then also relieve anxiety, brain fog, cell mutation, fatigue, chronic inflammation, stress, mental impairment or decline, high blood sugar, blood pressure and cholesterol levels, neurodegenerative diseases like Alzheimer’s disease, and many other illnesses and chronic health conditions.
There is, unfortunately, one issue with Stonehenge Health Dynamic Mushrooms that we do have to point out. This is that, other than lion’s mane mushrooms, all of the medical mushrooms present have been used in doses that are much lower than those necessary to produce the optimal health effects they can.
Regardless, Stonehenge Health Dynamic Mushrooms mix one of the most potent doses of lion’s mane mushrooms with other medicinal mushrooms proven to benefit the immune system.
That is why it is one of the best choices for people who want to rely primarily on lion’s mane mushrooms to support their immune system and boost the production of natural killer cells.
Pros
- It contains one of the most potent doses of lion’s mane mushroom you will see
- It uses a range of mushroom extracts that boost the immune system and overall health in many ways.
- Stimulates the production of immune cells and dendritic cells
Cons
- One of the most expensive mushroom supplements on the market
- Most immune compounds are present in doses that are far lower than optimal
Smart Habits Triple Immune
Smart Habits Triple Immune is a certified organic, GMO and gluten-free supplement made in GMP-certified and FDA-registered facilities and 3rd party tested to ensure its quality and purity.
This supplement supports the immune system, made with extracts from three medicinal mushrooms – reishi, maitake (grifola frondosa), and shiitake. It is high in beta-glucans and contains no fillers, additives, or preservatives.
Between them, they boost brain, heart, immune system, and urinary tract health and functions, as your mood, sleep quality, strength, stamina, energy levels, and weight loss, and combat stress, anxiety, high blood sugar, pressure and cholesterol, inflammation, metabolic syndrome, fatigue, and other issues.
Smart Habits Triple Immune admittedly does use lower doses of most of its ingredients than is optimal. However, it contains one of the most potent doses of shiitake mushrooms that you will find while being reasonably priced.
That is why, if you are looking to use shiitake mushrooms to boost the health and functions of your immune system or are shopping on a budget, Smart Habits Triple Immune may be one of the best options for you to try.
Pros
- Contains one of the most potent doses of shiitake mushrooms you will find
- Very reasonably priced
Cons
- It uses a minimal selection of ingredients, which limits its range of potential effects.
- Outside of shiitake mushrooms, its ingredients are in doses far lower than optimal.
Genius Mushrooms
Genius Mushrooms is a supplement designed to boost your mental clarity, immune system, mood, ATP production, energy levels, memory, oxygen utilization, aerobic capacity, and athletic endurance. It is also very reasonably priced, so it is a supplement that everyone can afford to use.
The Genius Mushrooms formula is rich in beta-glucans. It solely uses organic mushrooms that we have already looked at, including lion’s mane mushrooms, cordyceps mushrooms, and reishi mushrooms.
Together, they will boost your brain, heart, immune system, testicle functions, performance and health, focus, clarity, mood, memory, concentration, physical performance, brain cell and nerve growth, and blood flow to the brain.
They can also be used to prevent or combat mental decline, high blood pressure, Alzheimer’s disease, tumors, chronic diseases and health conditions, and inflammation.
Genius Mushrooms has some issues, as lion’s mane extract is the only ingredient properly dosed, while all of the other mushrooms need to be used in more diverse formulas to produce their full effects. However, this is not surprising, given that it is designed as a budget supplement.
This is why, even though we know it will not be the right choice for everyone, we consider Genius Mushrooms the best choice for people looking to boost their immune system by consuming mushrooms while shopping on a very tight budget.
Pros
- Uses a range of mushrooms rich in beta-glucans that are proven to boost your immune system
- Lion’s mane extract is present in its optimal dose
- 100 percent organic and very reasonably priced
Cons
- It contains only a few ingredients, limiting its potential benefits.
- Most of the ingredients are present in doses lower than optimal
- Two of the mushrooms will not produce optimal results in these doses without being used in a more diverse formula
Final Thoughts On The Best Mushroom Supplements For Immune Support
Culinary mushrooms may be a great inclusion in a healthy diet, but as traditional medicine has shown us, they can also boost the immune system. You can use several supplements to make the most of these effects, but the best one for most people is Nootrum Mushrooms.
Packed with potent doses of beta-glucans and a wide range of clinically proven medicinal mushrooms, Nootrum Mushrooms can boost your cytokine production and the health and functions of your immune system, at the same time benefiting the rest of your body and boasting a very reasonable price tag.
If Nootrum Mushrooms does not seem like the right supplement for you, then one of the other choices on this list surely will do. For everyone else, though, we highly recommend that you try Nootrum Mushrooms and see how it can benefit your immune system and health.
