LOS ANGELES — A growing brush fire was threatening thousands of homes in Brentwood and other hillside communities on the west side of Los Angeles, burning homes and prompting widespread evacuations early Monday.

The Getty fire broke out shortly after 1:30 a.m. along the 405 Freeway near the Getty Center and spread to the south and west, rapidly burning more than 500 acres and sending people fleeing from their homes in the dark. About 10,000 structures have been placed under mandatory evacuation orders.

The evacuation zone was described by fire officials as a box: Mulholland Drive on the north side, the 405 on the east, Sunset Boulevard on the south and Temescal Canyon Road on the west.

Los Angeles Fire Department Chief Ralph Terrazas said despite firefighters’ efforts, at least five homes, including some on Tigertail Road, have been destroyed in the blaze. That number likely will climb in the coming hours.

Mayor Eric Garcetti urged residents to leave if they are under mandatory evacuation orders, saying some have had only 15 minutes to flee.

“Get out when we say get out,” he said, urging homeowners to not try to fight the fire with garden hoses. “The only thing you cannot replace is you and your family.”

The roughly 500 firefighters battling the blaze early Monday braced for a challenging fight as fire weather conditions are expected to worsen through the day. Pre-dawn, embers were being cast a mile ahead of the body of the fire amid moderate winds. Thick smoke was visible across the Los Angeles Basin.

Fire officials advised residents outside the mandatory evacuation zone but in the fire area to prepare to leave. UCLA and other areas east of the 405 are not under an evacuation warning.

“It’s a dangerous season right now,” Terrazas said. “We have not had any significant rainfall for a period of time. That’s why we’re very concerned about these weather conditions.”

It was still dark on Tigertail Road when firefighters used hoses to douse hot spots smoldering near homes, sending rivers of water running down the street. A resident stood in his driveway in his bare feet, as his wife spoke to the police about where to evacuate.

Firetrucks lined the street, smoke choked the air and ash rained down as residents hurried to pack valuables into their cars. A woman pointed at a charred home on the street.

“That’s my neighbor’s house,” she said.

Around 5 a.m., winds at nearby Franklin Canyon Park east of the Sepulveda Pass were 10 mph, with gusts of up to 17 mph and a relative humidity of 23%, which is relatively dry. As the morning wears on, sustained winds from the northeast to the southwest could increase to 20-30 mph, with gusts up to 40 mph. It’s possible gusts could get up to 45 mph before they lessen in the early afternoon, National Weather Service meteorologist Lisa Phillips said.

Even worse, minimum relative humidity could fall into the single digits, perhaps as low as 5%. Temperatures in the area Monday are expected to top out in the upper 70s.

“As we heat up, we’re not going to get any more moisture in the area,” Phillips said. “The winds are still going to be strong through the morning hours.”

The fire was threatening some of Los Angeles’ most affluent neighborhoods. Among those evacuated was Lakers star LeBron James, who said on Twitter: “Had to emergency evacuate my house and I’ve been driving around with my family trying to get rooms. No luck so far!”

Authorities drove through neighborhood streets with flashing lights ordering residents to leave.

Ray Vafa, 59, stood on his driveway along Kenter Avenue in the dark, where the mandatory evacuation had left the neighborhood empty. Across the street, smiling pumpkin and ghost decorations were still sitting on a front lawn. Strong winds tore through ghosts strung up in trees.

“I’m just waiting it out,” he said. His wife and their poodle, Charlie Brown, had left earlier in the morning after they received the alerts. Vafa wasn’t too worried when the first notification arrived. After all, it had been raining he night before, he said.

“The second alert — it really alerted us,” he said.

In the 20 years they’ve lived in their home, they’ve never been under a mandatory evacuation order.

Farther down the street, a man who declined to give his name watched firetrucks lining Sunset Boulevard. The Brentwood resident was on the phone, trying to figure out whether he should leave. He has two cars and wouldn’t be able to drive them both.

“I have to figure out what I’m going to do with my Ferrari,” the 47-year-old man said.

Mount St. Mary’s University was surrounded by flames early Monday, and a campus spokeswoman said all 450 students have been safely evacuated to the school’s Doheny campus near downtown.

Diana Rodriguez, a second-year business major at the university, was studying for her Principles of Management class when the lights flicked out for about a minute at 1:30 a.m. Five minutes later, she smelled smoke. But she had smelled smoke last week, drifting south from the Tick fire in Santa Clarita. She figured whatever fire was burning now was similarly far away.

Then, around 2:30 a.m., resident assistants banged on the door of Rodriguez’s dorm. Everyone needed to gather their things and evacuate, they said.

Rodriguez grabbed her laptop, phone, camera and chargers, stuffed her backpack with snacks and water, and left her dorm in pajamas. The sky was blood red.

“Really, really red and orange —pretty, but a little freaky too,” she recalled.

Ash floated in the air. Her eyes stung from the smoke.

They put on masks and followed a road down the mountainside. Some students griped about having to evacuate while others were laughing “either because they didn’t know what was happening or as a coping mechanism,” Rodriguez said.

The students were picked up about halfway down the mountainside by ambulances, which ferried some to the school’s Doheny campus and others, like Rodriguez, to an evacuation center in Westwood.

Helicopters and aircraft were making night drops along the fire line in a fight to protect homes. Fixed-wing aircraft began making retardant drops shortly after sunrise. The cause of the blaze is not yet known, fire officials said, but Garcetti said it was not caused by homeless camp fires.

The speed of the fire — whipped by strong Santa Ana winds — took many by surprise as they rushed to evacuate. As the flames licked closer, some were reminded of the Skirball fire, which tore through the region in 2017.

Chad Elbert, 43, FaceTimed his wife from Mulholland and Walt Disney drives, where he had pulled over to get a look at the fire early Monday. The couple live a mile up the road and had woken up to the emergency alerts on their phones before 3 a.m.

They couldn’t smell smoke from where they lived and wondered whether they’d end up being evacuated.

“It’s a risk you take living out here,” Elbert said.

When the couple first bought their home, the Skirball fire broke out four days later. Although they didn’t evacuate, they were packed and ready to go.

In the predawn darkness Monday, Elbert watched the flames from a safe distance.

“It’s very surreal,” he said. “It’s like a scene out of a movie.”